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WHAT DOES LORTAB 10/500MG DO? Lortab 10/500mg is prescribed for treating moderate to acute pain and is a combinational drug containing an opioid and a non-opioid analgesic. Lortab 10/500 mg contains 10mg of Hydrocodone bitartrate and 500mg of Acetaminophen. Hydrocodone being a narcotic pain reliever helps the patient by working inside the brain and changing …